안녕하세요. U of I에 있는 제세영입니다.
제가 이번에 AHA Postdoctoral Fellowship Grant를 2년간 받게 되었습니다 (2006년 7월 - 2008년 6월).
Proposed Research Plan의 Specific Aims부분을 올려드립니다.
박사후 과정을 준비하시거나 박사후 과정에 계시는 분들에게 도움이 되었으면 합니다. 구체적인 준비과정과 내용은 AHA 홈페이지에 자세히 설명되어 있습니다.
PROJECT TITLE: Cardiac Autonomic and Vascular Function Alteration by Acute Systemic Inflammation: Effect of aging and physical activity
OVERALL AIM: Although acute systemic inflammation or infection transiently increases risk of cardiovascular events, the underlying mechanisms are not fully understood. Cardiac autonomic dysfunction (increased sympathetic and decreased parasympathetic tone) increases the risk of sudden cardiac death. Recent observational studies suggest that reduced heart rate variability, an index of autonomic function, is also associated with inflammatory markers. Furthermore, parasympathetic stimulation impacts immune function through the cholinergic anti-inflammatory pathway and inflammation affects cardiac autonomic control. Thus, inflammation may cause deterioration of cardiac autonomic function, but direct evidence for this is lacking in humans. Therefore, the primary aim of this study is to address if inflammation causes a deterioration of cardiac autonomic function.
Advancing age is associated with progressive impairments in the autonomic nervous, cardiovascular and immune systems. Since there are age-related changes in innate immunity and a dysregulation of inflammatory markers, it is possible that acute systemic inflammation may have negative effects on cardiac autonomic and vascular function but this is not well understood. Therefore, a second question is: Is aging associated with a deterioration of cardiac autonomic and vascular function induced by acute systemic inflammation?
Moderate exercise protects against mortality from influenza virus infection in experimental studies. However, underlying mechanisms relating exercise effects to influenza virus infection are not understood. Acute systemic inflammation leads to endothelial dysfunction and increased arterial stiffness. Physical activity reduces inflammatory markers, and increases cardiac autonomic, immune and vascular function. Thus, it is possible that physical activity can partially prevent the negative cascade of events produced by acute inflammation. Therefore, a major question is: Can physical activity prevent the negative effect of acute systemic inflammation on cardiac autonomic and vascular function?
Aim 1; To examine the effect of an acute systemic inflammatory response on cardiac autonomic nervous system control in a randomized, double-blind, sham procedure-controlled crossover design. We hypothesize that the acute systemic inflammatory response will temporarily reduce cardiac autonomic nervous system control.
Aim 2; To evaluate the effect of aging on cardiac autonomic and vascular function in response to acute systemic inflammation. We hypothesize that the acute systemic inflammatory response will be exaggerated or prolonged in older compared to young individuals, thereby producing greater decrements in cardiac autonomic and vascular function compared to the young groups.
Aim 3; To evaluate the effect of physical activity by comparing the effect of acute systemic inflammation on cardiac autonomic and vascular function in physically active and sedentary groups. We hypothesize that the acute systemic inflammatory response will be lower in physically active individuals, thereby producing lesser decrements in cardiac autonomic and vascular function compared to their age-matched sedentary peers.